Director/PDMR Shareholding

AstraZeneca PLC
27 February 2008


Transaction by Persons Discharging Managerial Responsibilities
Disclosure Rule DTR 3.1.4



We hereby inform you that the interest of David R. Brennan, a Director of the
Company, in the shares of AstraZeneca PLC has changed as detailed below.  Mr
Brennan has interests in both the Ordinary Shares and the American Depositary
Shares (ADSs) of AstraZeneca PLC.  One ADS equals one Ordinary Share.



On 25 February 2008, Mr Brennan received an allocation of 16,810 Ordinary Shares
under the previously disclosed arrangements relating to his annual bonus for
2007 whereby he is required to defer a portion of the bonus earned into shares
for a period of three years.  The shares were allocated at a price of 1999 pence
per share.  Mr Brennan will become beneficially entitled to these shares on 25
February 2011.



On 25 February 2008, Mr Brennan received a scheduled distribution out of the
AstraZeneca US Executive Deferral Plan, a unitised stock fund established in
2000, in which Mr Brennan, in common with other participating US executives, is
deemed to have a notional interest in ADSs calculated by reference to the fund
value and the closing price of AstraZeneca ADSs.  Following this scheduled
distribution on 25 February 2008, Mr Brennan had a notional interest in 40,286
ADSs within the AstraZeneca US Executive Deferral Plan by reference to the
closing price on 25 February 2008 of US$39.47.



Immediately prior to the above transactions, Mr Brennan had an interest in
217,618 Ordinary Shares and 143,617 AstraZeneca ADSs.  As a result of these
transactions, Mr Brennan's interest is now 234,428 Ordinary Shares and 121,435
AstraZeneca ADSs, including the notional interest in ADSs in the AstraZeneca US
Executive Deferral Plan referred to above.  This interest represents
approximately 0.024% of the Company's issued ordinary capital.





G H R Musker
Company Secretary
27 February 2008


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