Director/PDMR Shareholding

AstraZeneca PLC
26 March 2008



Transaction by Persons Discharging Managerial Responsibilities

Disclosure Rules DTR 3.1.4R



We hereby inform you that the interest of David R. Brennan, a Director of the
Company, in the shares of AstraZeneca PLC has changed as detailed below.  Mr
Brennan has interests in both the Ordinary Shares and the American Depositary
Shares (ADSs) of AstraZeneca PLC.  One ADS equals one Ordinary Share.



On 24 March 2008, Mr Brennan became unconditionally entitled to a final award of
26,762 ADSs on the partial vesting of a previously announced original target
award of 27,877 ADSs, which were awarded to him in March 2005 under the terms of
the AstraZeneca US Executive Performance Share Plan.  Mr Brennan has ceased to
have an interest in the 1,115 ADSs of the original target award that did not
vest.  After certain mandatory tax deductions, Mr Brennan has received 17,715
ADSs into a personal brokerage account.



The closing price of AstraZeneca ADSs on 20 March 2008 was US$37.63.



Immediately prior to the above transactions, Mr Brennan had an interest in
234,428 Ordinary Shares and 121,435 AstraZeneca ADSs.  As a result of these
transactions, Mr Brennan now has an interest in 234,428 Ordinary Shares and
111,273 AstraZeneca ADSs.  This interest represents approximately 0.024% of the
Company's issued ordinary capital.





G H R Musker
Company Secretary
26 March 2008


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