Director/PDMR Shareholding

AstraZeneca PLC
08 January 2008

Transaction by Person Discharging Managerial Responsibilities

Disclosure Rules DTR 3.1.2R





We hereby inform you that on 31 December 2007, Dr John Patterson, a Director of
AstraZeneca PLC and a person discharging managerial responsibilities, gave an
irrevocable instruction to exercise options over 625 AstraZeneca PLC USD0.25
Ordinary Shares as follows:



- option over 374 shares at an option price of 1756 pence per share granted
under the AstraZeneca Savings Related Share Option Scheme



- option over 251 shares at an option price of 2262 pence per share granted
under the AstraZeneca Savings Related Share Option Plan.



We further inform you that the exercise date of these options was 4 January
2008.



Following these exercises Dr Patterson holds options over 236,091 AstraZeneca
PLC UDS0.25 Ordinary Shares.



We confirm that Dr Patterson retained the 625 shares acquired and, as a result,
his interest in shares has increased to 131,912 AstraZeneca PLC UDS0.25 Ordinary
Shares, which represents approximately 0.009% of the current issued capital.





G H R Musker

Company Secretary

8 January 2008


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