Director/PDMR Shareholding

AstraZeneca PLC
31 March 2008


Transaction by Persons Discharging Managerial Responsibilities
Disclosure Rules DR 3.1.4R

We hereby inform you that on 28 March 2008 the following Directors of
AstraZeneca PLC were each granted an award under the terms of the AstraZeneca
Performance Share Plan over the Company's USD0.25 Ordinary Shares.
                                                        
                                                       
                  Target      Award                    Total interest Percentage 
                  number      price    Normal          in  shares     of shares 
                  of shares   per      vesting         after this     in issue
Name of Director  awarded     share    date            award           

D R Brennan       161,546     1882p    28 March 2011   See below      See below

S Lowth           58,448      1882p    28 March 2011   76,192         0.005%

J S Patterson     57,385      1882p    28 March 2011   197,107        0.014%

The AstraZeneca Performance Share Plan was approved by shareholders at the
Company's AGM in 2005.  Awards made under the Plan may not generally vest before
the third anniversary of the relevant date of grant nor unless the specified
performance target(s) have been met at the end of the three year period which,
for this award, is 1 January 2008 to 31 December 2010.

The performance target that applies to this award is the Company's Total
Shareholder Return ('TSR') compared to the TSR of a selected peer group of 12
other pharmaceutical companies.  The actual number of shares to which a
participant may become unconditionally entitled will depend on the extent to
which the performance target(s) have been met.  A summary of the Plan, including
a more detailed explanation of the performance target(s), can be found in the
AstraZeneca Annual Report and Form 20-F Information 2007 which is available on
the Company's website www.astrazeneca.com.

Mr Brennan has interests in the Company's Ordinary Shares and American
Depositary Shares (ADSs).  One ADS equals one Ordinary Share.  In total, Mr
Brennan now has an interest in 395,974 Ordinary Shares and 111,273 ADSs, which
together represent approximately 0.035% of the number of shares currently in
issue.


G H R Musker
Company Secretary
31 March 2008


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