Director/PDMR Shareholding

AstraZeneca PLC
31 March 2008

Transaction by Persons Discharging Managerial Responsibilities
Disclosure Rules DTR 3.1.4R

We hereby inform you that on 28 March 2008 the following individuals, who are
all persons discharging managerial responsibilities, were granted options under
the AstraZeneca Share Option Plan over the Company's USD0.25 Ordinary Shares or,
in the case of D Mott, L Tetrault and A Zook, over the Company's American
Depositary Shares (ADSs).  One ADS equals one Ordinary Share

                       Number of shares over which    Exercise price per   Period when exercisable
Name of individual     option is granted              share

B Angelici             49,628                         1882p                28.3.11-27.3.18

J Lundberg             48,445                         1882p                28.3.11-27.3.18

D Mott                 121,478                        US$37.76             28.3.11-27.3.18

D Smith                36,131                         1882p                28.3.11-27.3.18

L Tetrault             67,302                         US$37.76             28.3.11-27.3.18

A Zook                 96,971                         US$37.76             28.3.11-27.3.18


The options will become exercisable on 28 March 2011 subject to certain
performance conditions.  The conditions, which will not be subject to any
retesting, are that the earnings per share of the Company must increase by the
increase in the UK Retail Prices Index plus 5% per annum on average over three
years, and that no significant unforeseen event has taken place which, in the
reasonable opinion of the Remuneration Committee, has resulted in major
reputational damage to AstraZeneca, and the circumstances of which are
exceptional enough to justify the option not vesting and becoming exercisable.
Failure to satisfy either or both of these conditions will result in the lapse
of the option in its entirety.

G H R Musker
Company Secretary
31 March 2008




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