Transaction by Person Discharging Managerial Responsibilities
Disclosure Rules DTR 3.1.4R
We hereby inform you that the interest of David Brennan, a Director of the Company, in the shares of AstraZeneca PLC has changed as detailed below.
On 2 March 2010, Mr Brennan exercised an option over 32,727 AstraZeneca PLC American Depositary Shares (ADSs) at an option price of $44.00 per ADS. One ADS equals one Ordinary Share. The option, which was granted to Mr Brennan in March 2000, was due to expire on 16 March 2010, if not exercised before then.
Following the exercise, Mr Brennan sold all of the 32,727 ADSs so acquired at a price of $44.35 per ADS.
As a result of this transaction, Mr Brennan now holds options over 322,519 ADSs and 592,975 Ordinary Shares.
A C N Kemp
Company Secretary
3 March 2010