Director/PDMR Shareholding

AstraZeneca PLC
29 March 2006



Transaction by Persons Discharging Managerial Responsibilities
Disclosure Rules DR 3.1.2R


We hereby inform you that on 28 March 2006, Martin Nicklasson, Executive
Vice-President, Global Marketing and Business Development, a person discharging
managerial responsibilities, sold 273 AstraZeneca PLC USD0.25 Ordinary Shares at
a price of 2914 pence per share.


G H R Musker
Company Secretary
29 March 2006






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