Director/PDMR Shareholding

AstraZeneca PLC
26 March 2007

Transaction by Person Discharging Managerial Responsibilities
Disclosure Rules DR 3.1.2R


We hereby inform you that on 23 March 2007, Tony Bloxham, Executive
Vice-President, Human Resources, a person discharging managerial
responsibilities, exercised options over 4,971 AstraZeneca PLC USD0.25 Ordinary
Shares as follows:

- option over 2,069 shares at an option price of 1740 pence per share

- option over 2,902 shares at an option price of 1933 pence per share

The options were granted to Mr Bloxham under the Company's 1994 Executive Share
Option Plan in 1997 and were due to expire in April 2007 and August 2007
respectively if not exercised before then.

We also inform you that on 23 March 2007, Mr Bloxham sold the 4,971 shares
acquired from the exercise at a price of 2798 pence per share.


G H R Musker
Company Secretary
26 March 2007


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