Transaction in Own Shares

AstraZeneca PLC
18 November 2005


                    REPURCHASE OF SHARES IN ASTRAZENECA PLC

AstraZeneca PLC announced that on 17 November 2005, it purchased for
cancellation 500,000 ordinary shares of AstraZeneca PLC at a price of 2590 pence
per share. Upon the cancellation of these shares, the number of shares in issue
will be 1,588,206,728.

G H R Musker
Company Secretary
18 November 2005


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