CardioQ-ODM in emergency abdominal surgery

RNS Number : 2711A

Deltex Medical Group PLC

29 March 2012

 



Deltex Medical Group plc

Results of first randomised trial of CardioQ-ODM™ in emergency abdominal surgery presented at World Congress of Anaesthesia

29 March 2012 - Deltex Medical Group plc, the global leader in oesophageal Doppler monitoring (ODM), announces the results of the first randomised controlled clinical trial of the impact of using CardioQ-ODM during emergency abdominal surgery.

Doctors from Hospital Nacional Alberto Sabogal in Lima, Peru, one of the leading hospitals in South America, yesterday presented the results of their trial on 250 patients undergoing emergency abdominal surgery at the World Congress of Anaesthesia, being held this week in Buenos Aries, Argentina.

The results showed the following benefits from CardioQ-ODM guided fluid management:

·      48% reduction in cardiovascular complications

·      38% reduction in respiratory complications

·      73% reduction in surgical site infections

·      62% reduction in kidney complications

·      34% reduction in use of intensive care units after surgery

·      2.7 day (25%) reduction in length of hospital stay

The trial authors concluded:

"For patients undergoing emergency abdominal surgery the intraoperative oesophageal Doppler monitoring leads to a shorter hospital and intensive care unit stay and decreased major postoperative complications."

Ewan Phillips, Chief Executive of Deltex Medical, commented:

"This trial reinforces the proven clinical and economic benefits of CardioQ-ODM use during surgery. It provides an evidence base locally in South America and specifically addresses emergency surgery in a discipline where we are already achieving strong penetration in elective cases.

"The release of these results is timely. One of the four English NHS regions is introducing a CQUIN financial incentive from 1 April 2012 specifically to improve fluid management in emergency abdominal surgery. This follows a CQUIN incentive for fluid management monitoring in elective colorectal surgery in the year ending 31 March 2012 which has resulted in adoption rates of 80% or higher in several hospitals in the current quarter."

For further information, please contact:-

Deltex Medical Group plc                                    01243 774 837

Nigel Keen, Chairman                                         [e-mail]

Ewan Phillips, Chief Executive                            [e-mail]

Paul Mitchell, Finance Director                            [e-mail]

Nominated Adviser & Broker

Arden Partners plc                                             020 7614 5900

Chris Hardie                                                      [e-mail]

Jamie Cameron                                                  [e-mail]

Kreab Gavin Anderson                                        020 7074 1800

Robert Speed                                                    [e-mail]

Deborah Walter                                                  [e-mail]

Notes for Editors

Deltex Medical manufactures and markets the CardioQ-ODMÔ system. Oesophageal Doppler monitoring using the CardioQ-ODM is the only therapy to measure blood flow in the central circulation in real time. Minimally invasive, easy to set up and quick to focus, the device generates a low-frequency ultrasound signal, which is highly sensitive to changes in flow and measures them immediately. Randomised, controlled trials using Doppler have demonstrated that early fluid management intervention will reduce post-operative complications, reduce intensive care admissions, and reduce the length of hospital stay.

The CardioQ-ODM has two distinct established clinical applications: firstly, to guide fluid management during surgery and secondly, to monitor cardiac output in critical care settings.

Surgical market

In March 2011 the National Institute for Health & Clinical Excellence ('NICE') recommended that CardioQ-ODM be considered for use in patients undergoing major and high risk surgery and in high risk patients undergoing major surgery. NICE estimated the applicable number of such patients in the NHS in England alone to be over 800,000 each year. CardioQ-ODM has been shown to be effective in both elective and emergency surgery and with both general and regional anaesthetics. This recommendation was specific to CardioQ-ODM and was based on the robust evidence base that it enjoys.

The NICE evaluation and recommendation confirms that the potential global market for CardioQ-ODM in surgery includes tens of millions of patients, even if confined to developed health economies: the most conservative estimate of the potential value of the market opportunity Deltex Medical has created is in excess of £1 billion per annum. The Company's core focus is on building market leading positions in this surgical market, both geographically and by type of surgery.

Critical care market

In critical care settings, well-equipped hospitals will often have more than one cardiac output monitoring technology available. In this environment, ODM's strengths are that it is quick to set up, easy to use, safe, low cost and the ideal technology for a patient in crisis requiring rapid or frequent intervention. The potential market for cardiac output monitoring in critical care is a fraction of the size of that for intra-operative fluid management.

Through the recent launch of the CardioQ-ODM+, Deltex Medical has incorporated pulse pressure variation, the best validated parameter from the Pulse Pressure Waveform Analysis ('PPWA') approach to monitoring cardiac output. Note that, in surgery, adding PPWA parameters does not expand per se the market potential of ODM, the Company's clinical and market research indicates that it may help accelerate some clinicians' acceptance of the value of ODM measured flow variables.

Company goal

Our goal is to make oesophageal Doppler monitoring (ODM) a standard of care for patients in both these markets. We believe that, in most modern health systems, it is essential to have a robust evidence base of both clinical benefit and cost effectiveness in order to achieve system-wide adoption of a new medical technology. Deltex Medical is one of the very first medical technology companies to have completed the investment necessary to build such an evidence base: as a result, use of ODM during surgery has the proven potential to deliver both clinical and economic benefits that are material at each of patient, hospital and system level.

The Company is currently in the implementation phase of achieving this goal in a number of territories worldwide and there are already over 2,500 CardioQ-ODMs currently in use in hospitals worldwide and distribution arrangements are in place in over 30 countries.

 

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