Annual Information Update

GlaxoSmithKline PLC
31 March 2006


  ANNUAL INFORMATION UPDATE FOR GLAXOSMITHKLINE PLC FOR THE 12 MONTHS UP TO 31
                                   MARCH 2006


In accordance with the requirements of Prospectus Rule 5.2.1R please find below
an Annual Information Update for GlaxoSmithKline plc ("The Company"). The
information referred to in this Update was up to date at the time the
information was published, but some information may now be out of date.

To avoid an unnecessarily lengthy document the following are summaries of the
information and documents published, or made available to the public, by the
Company throughout the twelve months ended 31 March 2006.

1.      Announcements made via RNS, a Regulatory Information Service.

The announcements listed below were published on the London Stock Exchange via
RNS, a Regulatory Information Service and can be obtained from their website
www.londonstockexchange.com  or the Company's website www.gsk.com

Date                                 Headline

29/03/2005                           FDA Approval of Boniva
29/03/2005                           Director Shareholding
29/03/2005                           Transaction in Own Shares
29/03/2005                           Director Shareholding
30/03/2005                           Transaction in Own Shares
30/03/2005                           Director Shareholding
30/03/2005                           Director Shareholding
31/03/2005                           Transaction in Own Shares
01/04/2005                           Director Shareholding
05/04/2005                           Director Shareholding
06/04/2005                           Director Declaration
06/04/2005                           Director Shareholding
08/04/2005                           Director Shareholding
08/04/2005                           Director Shareholding
11/04/2005                           Director Shareholding
11/04/2005                           Director Shareholding
11/04/2005                           Director Shareholding
12/04/2005                           Director Shareholding
12/04/2005                           Director Shareholding
12/04/2005                           Director Shareholding
13/04/2005                           Director Shareholding
13/04/2005                           Director Shareholding
13/04/2005                           Director Shareholding
14/04/2005                           Director Shareholding
15/04/2005                           Director Shareholding
18/04/2005                           Director Shareholding
18/04/2005                           Director Shareholding
18/04/2005                           Director Shareholding
19/04/2005                           Director Shareholding
20/04/2005                           Director Shareholding
21/04/2005                           Holding(s) in Company
22/04/2005                           Director Shareholding
22/04/2005                           Holding(s) in Company
25/04/2005                           Director Shareholding
26/04/2005                           Director Shareholding
26/04/2005                           Director Shareholding
28/04/2005                           Agreement on consent decree
28/04/2005                           1st Quarter Results
28/04/2005                           Q1 Dividend Record Date
29/04/2005                           Director Shareholding
03/05/2005                           Acquisition of Corixa Corp
03/05/2005                           Director Shareholding
03/05/2005                           Director Shareholding
03/05/2005                           Director Shareholding
04/05/2005                           Director Shareholding
04/05/2005                           Director Shareholding
05/05/2005                           Director Shareholding
05/05/2005                           Transaction in Own Shares
06/05/2005                           Director Shareholding
09/05/2005                           Director Shareholding
09/05/2005                           Transaction in Own Shares
10/05/2005                           Additional Listing
10/05/2005                           Director Shareholding
10/05/2005                           Director Shareholding
11/05/2005                           Director Shareholding
11/05/2005                           Transaction in Own Shares
12/05/2005                           Director Shareholding
12/05/2005                           Transaction in Own Shares
13/05/2005                           Listing Particulars
13/05/2005                           Director Shareholding
13/05/2005                           Director Shareholding
13/05/2005                           Transaction in Own Shares
16/05/2005                           Update on Lapatinib
16/05/2005                           Director Shareholding
16/05/2005                           Director Shareholding
17/05/2005                           Director Shareholding
17/05/2005                           Transaction in Own Shares
18/05/2005                           Director Shareholding
18/05/2005                           Director Shareholding
18/05/2005                           Director Shareholding
19/05/2005                           Director Shareholding
19/05/2005                           Transaction in Own Shares
20/05/2005                           Director Shareholding
20/05/2005                           Transaction in Own Shares
23/05/2005                           Director Shareholding
23/05/2005                           Director Shareholding
23/05/2005                           Transaction in Own Shares
24/05/2005                           Director Shareholding
24/05/2005                           Director Shareholding
24/05/2005                           Transaction in Own Shares
25/05/2005                           Board committee change
25/05/2005                           Result of AGM
25/05/2005                           Director Shareholding
27/05/2005                           Director Shareholding
27/05/2005                           Transaction in Own Shares
31/05/2005                           AGM Statement
31/05/2005                           Director Shareholding
31/05/2005                           Transaction in Own Shares
01/06/2005                           Transaction in Own Shares
01/06/2005                           Director Shareholding
02/06/2005                           Director Shareholding
06/06/2005                           Director Shareholding
06/06/2005                           Transaction in Own Shares
07/06/2005                           Director Shareholding
08/06/2005                           Director Shareholding
08/06/2005                           Director Shareholding
09/06/2005                           Director Shareholding
09/06/2005                           Transaction in Own Shares
10/06/2005                           Director Shareholding
10/06/2005                           Transaction in Own Shares
10/06/2005                           Director Shareholding
13/06/2005                           Director Shareholding
13/06/2005                           Director Shareholding
14/06/2005                           Director Shareholding
14/06/2005                           Director Shareholding
14/06/2005                           Transaction in Own Shares
15/06/2005                           Director Shareholding
15/06/2005                           Transaction in Own Shares
16/06/2005                           Transaction in Own Shares
20/06/2005                           Director Shareholding
20/06/2005                           Director Shareholding
20/06/2005                           Transaction in Own Shares
21/06/2005                           Director Shareholding
21/06/2005                           Director Shareholding
21/06/2005                           Transaction in Own Shares
22/06/2005                           Director Shareholding
23/06/2005                           Director Shareholding
24/06/2005                           Director Shareholding
27/06/2005                           Resupply of Paxil CR
27/06/2005                           Director Shareholding
27/06/2005                           Director Shareholding
28/06/2005                           Director Shareholding
30/06/2005                           Research Update - Vaccines
30/06/2005                           Director Shareholding
01/07/2005                           Director/PDMR Shareholding
04/07/2005                           Director/PDMR Shareholding
04/07/2005                           Director/PDMR Shareholding
04/07/2005                           Director/PDMR Shareholding
06/07/2005                           Director/PDMR Shareholding
06/07/2005                           Director/PDMR Shareholding
07/07/2005                           Director/PDMR Shareholding
08/07/2005                           Director/PDMR Shareholding
08/07/2005                           Director/PDMR Shareholding
08/07/2005                           Director/PDMR Shareholding
11/07/2005                           Director/PDMR Shareholding
11/07/2005                           Director/PDMR Shareholding
11/07/2005                           Director/PDMR Shareholding
11/07/2005                           Director/PDMR Shareholding
11/07/2005                           Director/PDMR Shareholding
11/07/2005                           Director/PDMR Shareholding
12/07/2005                           Director/PDMR Shareholding
12/07/2005                           Director/PDMR Shareholding
12/07/2005                           Director/PDMR Shareholding
14/07/2005                           Director/PDMR Shareholding
14/07/2005                           Director/PDMR Shareholding
18/07/2005                           Director/PDMR Shareholding
18/07/2005                           Director/PDMR Shareholding
20/07/2005                           Director/PDMR Shareholding
21/07/2005                           Director/PDMR Shareholding
21/07/2005                           Director/PDMR Shareholding
25/07/2005                           Director/PDMR Shareholding
26/07/2005                           Director/PDMR Shareholding
26/07/2005                           Director/PDMR Shareholding
28/07/2005                           Interim Results
28/07/2005                           Director/PDMR Shareholding
29/07/2005                           Doc re. Interim Report
01/08/2005                           Director/PDMR Shareholding
01/08/2005                           Director/PDMR Shareholding
02/08/2005                           Director/PDMR Shareholding
02/08/2005                           Director/PDMR Shareholding
02/08/2005                           Director/PDMR Shareholding
02/08/2005                           Director/PDMR Shareholding
03/08/2005                           Director/PDMR Shareholding
03/08/2005                           Transaction in Own Shares
04/08/2005                           Transaction in Own Shares
05/08/2005                           Transaction in Own Shares
08/08/2005                           Director/PDMR Shareholding
09/08/2005                           Blocklisting Interim Review
09/08/2005                           Director/PDMR Shareholding
09/08/2005                           Transaction in Own Shares
10/08/2005                           Director/PDMR Shareholding
10/08/2005                           Transaction in Own Shares
10/08/2005                           Director/PDMR Shareholding
12/08/2005                           Transaction in Own Shares
16/08/2005                           Transaction in Own Shares
16/08/2005                           Director/PDMR Shareholding
16/08/2005                           Director/PDMR Shareholding
16/08/2005                           Director/PDMR Shareholding
16/08/2005                           Director/PDMR Shareholding
18/08/2005                           Transaction in Own Shares
19/08/2005                           Transaction in Own Shares
22/08/2005                           Transaction in Own Shares
22/08/2005                           Director/PDMR Shareholding
22/08/2005                           Director/PDMR Shareholding
22/08/2005                           Director/PDMR Shareholding
22/08/2005                           Director/PDMR Shareholding
22/08/2005                           Director/PDMR Shareholding
24/08/2005                           Transaction in Own Shares
25/08/2005                           Additional Listing
25/08/2005                           Transaction in Own Shares
26/08/2005                           Director/PDMR Shareholding
26/08/2005                           Director/PDMR Shareholding
30/08/2005                           Director/PDMR Shareholding
30/08/2005                           Director/PDMR Shareholding
30/08/2005                           Director/PDMR Shareholding
31/08/2005                           Director/PDMR Shareholding
31/08/2005                           Transaction in Own Shares
01/09/2005                           Director/PDMR Shareholding
01/09/2005                           Transaction in Own Shares
02/09/2005                           Transaction in Own Shares
02/09/2005                           Director/PDMR Shareholding
05/09/2005                           Director/PDMR Shareholding
05/09/2005                           Director/PDMR Shareholding
05/09/2005                           Director/PDMR Shareholding
06/09/2005                           Director/PDMR Shareholding
06/09/2005                           Transaction in Own Shares
07/09/2005                           Acquisition of ID Biomedical Corporation
07/09/2005                           Transaction in Own Shares
09/09/2005                           Director/PDMR Shareholding
09/09/2005                           Transaction in Own Shares
12/09/2005                           Director/PDMR Shareholding
12/09/2005                           Director/PDMR Shareholding
12/09/2005                           Transaction in Own Shares
13/09/2005                           Director/PDMR Shareholding
13/09/2005                           Director/PDMR Shareholding
13/09/2005                           Director/PDMR Shareholding
13/09/2005                           Director/PDMR Shareholding
13/09/2005                           Director/PDMR Shareholding
14/09/2005                           Director/PDMR Shareholding
15/09/2005                           Transaction in Own Shares
15/09/2005                           Transaction in Own Shares
16/09/2005                           Director/PDMR Shareholding
16/09/2005                           Transaction in Own Shares
19/09/2005                           Director/PDMR Shareholding
19/09/2005                           Transaction in Own Shares
20/09/2005                           Director/PDMR Shareholding
20/09/2005                           Director/PDMR Shareholding
20/09/2005                           Director/PDMR Shareholding
20/09/2005                           Transaction in Own Shares
21/09/2005                           Transaction in Own Shares
21/09/2005                           Director/PDMR Shareholding
22/09/2005                           Transaction in Own Shares
23/09/2005                           Director/PDMR Shareholding
23/09/2005                           Director/PDMR Shareholding
27/09/2005                           Director/PDMR Shareholding
27/09/2005                           Director/PDMR Shareholding
27/09/2005                           Transaction in Own Shares
27/09/2005                           Director/PDMR Shareholding
27/09/2005                           Director/PDMR Shareholding
27/09/2005                           Director/PDMR Shareholding
28/09/2005                           Transaction in Own Shares
28/09/2005                           Director/PDMR Shareholding
28/09/2005                           Director/PDMR Shareholding
29/09/2005                           Director/PDMR Shareholding
30/09/2005                           Director/PDMR Shareholding
30/09/2005                           Transaction in Own Shares
03/10/2005                           Director/PDMR Shareholding
03/10/2005                           Director/PDMR Shareholding
03/10/2005                           Director/PDMR Shareholding
04/10/2005                           Director/PDMR Shareholding
04/10/2005                           Director/PDMR Shareholding
05/10/2005                           Director/PDMR Shareholding
06/10/2005                           Director/PDMR Shareholding
07/10/2005                           Director/PDMR Shareholding
07/10/2005                           Director/PDMR Shareholding
07/10/2005                           Director/PDMR Shareholding
07/10/2005                           Director/PDMR Shareholding
10/10/2005                           Director/PDMR Shareholding
10/10/2005                           Director/PDMR Shareholding
10/10/2005                           Director/PDMR Shareholding
10/10/2005                           Director/PDMR Shareholding
11/10/2005                           Director/PDMR Shareholding
11/10/2005                           Director/PDMR Shareholding
11/10/2005                           Director/PDMR Shareholding
12/10/2005                           Director/PDMR Shareholding
12/10/2005                           Director/PDMR Shareholding
13/10/2005                           Director/PDMR Shareholding
13/10/2005                           Director/PDMR Shareholding
13/10/2005                           Director/PDMR Shareholding
13/10/2005                           Director/PDMR Shareholding
13/10/2005                           Director/PDMR Shareholding
14/10/2005                           Director/PDMR Shareholding
17/10/2005                           Director/PDMR Shareholding
17/10/2005                           Director/PDMR Shareholding
17/10/2005                           Director/PDMR Shareholding
18/10/2005                           Director/PDMR Shareholding
18/10/2005                           Director/PDMR Shareholding
19/10/2005                           Director/PDMR Shareholding
21/10/2005                           Director/PDMR Shareholding
21/10/2005                           Director/PDMR Shareholding
24/10/2005                           Director/PDMR Shareholding
24/10/2005                           Director/PDMR Shareholding
24/10/2005                           Director/PDMR Shareholding
24/10/2005                           Director/PDMR Shareholding
25/10/2005                           Director/PDMR Shareholding
25/10/2005                           Director/PDMR Shareholding
25/10/2005                           Director/PDMR Shareholding
25/10/2005                           Director/PDMR Shareholding
25/10/2005                           Director/PDMR Shareholding
26/10/2005                           Director/PDMR Shareholding
27/10/2005                           3rd Quarter Results
28/10/2005                           GSK Earnings Guidance
28/10/2005                           Transaction in Own Shares
28/10/2005                           Director/PDMR Shareholding
28/10/2005                           Director/PDMR Shareholding
31/10/2005                           Director/PDMR Shareholding
31/10/2005                           Transaction in Own Shares
31/10/2005                           Director/PDMR Shareholding
01/11/2005                           Transaction in Own Shares
01/11/2005                           Director/PDMR Shareholding
02/11/2005                           Director/PDMR Shareholding
03/11/2005                           Transaction in Own Shares
03/11/2005                           Director/PDMR Shareholding
03/11/2005                           Director/PDMR Shareholding
04/11/2005                           Transaction in Own Shares
04/11/2005                           Director/PDMR Shareholding
07/11/2005                           Transaction in Own Shares
07/11/2005                           Director/PDMR Shareholding
07/11/2005                           Director/PDMR Shareholding
07/11/2005                           Director/PDMR Shareholding
08/11/2005                           Transaction in Own Shares
08/11/2005                           Director/PDMR Shareholding
09/11/2005                           Director/PDMR Shareholding
09/11/2005                           Director/PDMR Shareholding
09/11/2005                           Director/PDMR Shareholding
10/11/2005                           Director/PDMR Shareholding
10/11/2005                           Director/PDMR Shareholding
11/11/2005                           Director/PDMR Shareholding
14/11/2005                           Director/PDMR Shareholding
14/11/2005                           Director/PDMR Shareholding
14/11/2005                           Director/PDMR Shareholding
15/11/2005                           Director/PDMR Shareholding
17/11/2005                           Director/PDMR Shareholding
18/11/2005                           Labeling Update
18/11/2005                           Director/PDMR Shareholding
22/11/2005                           Director/PDMR Shareholding
22/11/2005                           Director/PDMR Shareholding
22/11/2005                           Director/PDMR Shareholding
22/11/2005                           Director/PDMR Shareholding
23/11/2005                           Director/PDMR Shareholding
25/11/2005                           Director/PDMR Shareholding
30/11/2005                           R & D Oncology Day
30/11/2005                           Director/PDMR Shareholding
30/11/2005                           Transaction in Own Shares
30/11/2005                           Director/PDMR Shareholding
01/12/2005                           Transaction in Own Shares
02/12/2005                           Director/PDMR Shareholding
02/12/2005                           Transaction in Own Shares
02/12/2005                           Director/PDMR Shareholding
05/12/2005                           Director/PDMR Shareholding
05/12/2005                           Transaction in Own Shares
06/12/2005                           Director/PDMR Shareholding
06/12/2005                           Director/PDMR Shareholding
06/12/2005                           Director/PDMR Shareholding
06/12/2005                           Transaction in Own Shares
07/12/2005                           Director/PDMR Shareholding
07/12/2005                           Transaction in Own Shares
08/12/2005                           Director/PDMR Shareholding
08/12/2005                           Director/PDMR Shareholding
08/12/2005                           Transaction in Own Shares
08/12/2005                           Director/PDMR Shareholding
09/12/2005                           Director/PDMR Shareholding
09/12/2005                           Transaction in Own Shares
12/12/2005                           Transaction in Own Shares
12/12/2005                           Director/PDMR Shareholding
13/12/2005                           Director/PDMR Shareholding
13/12/2005                           Director/PDMR Shareholding
13/12/2005                           Transaction in Own Shares
14/12/2005                           Director/PDMR Shareholding
14/12/2005                           Transaction in Own Shares
15/12/2005                           Transaction in Own Shares
15/12/2005                           Director/PDMR Shareholding
15/12/2005                           Director/PDMR Shareholding
16/12/2005                           Director/PDMR Shareholding
16/12/2005                           Director/PDMR Shareholding
16/12/2005                           Transaction in Own Shares
19/12/2005                           Director/PDMR Shareholding
19/12/2005                           Director/PDMR Shareholding
19/12/2005                           Transaction in Own Shares
20/12/2005                           Director/PDMR Shareholding
20/12/2005                           Director/PDMR Shareholding
20/12/2005                           Director/PDMR Shareholding
21/12/2005                           Director/PDMR Shareholding
22/12/2005                           Directorate Change
22/12/2005                           Director/PDMR Shareholding
22/12/2005                           Director/PDMR Shareholding
22/12/2005                           Director/PDMR Shareholding
23/12/2005                           Director/PDMR Shareholding
28/12/2005                           Additional Listing
03/01/2006                           Director/PDMR Shareholding
03/01/2006                           Director/PDMR Shareholding
03/01/2006                           Director/PDMR Shareholding
03/01/2006                           Director/PDMR Shareholding
04/01/2006                           Director/PDMR Shareholding
05/01/2006                           Director/PDMR Shareholding
06/01/2006                           Director/PDMR Shareholding
06/01/2006                           Director/PDMR Shareholding
09/01/2006                           Director Declaration
09/01/2006                           Director/PDMR Shareholding
09/01/2006                           Director/PDMR Shareholding
09/01/2006                           Director/PDMR Shareholding
09/01/2006                           Director/PDMR Shareholding
09/01/2006                           Director/PDMR Shareholding
09/01/2006                           Director/PDMR Shareholding
10/01/2006                           Director/PDMR Shareholding
11/01/2006                           Director/PDMR Shareholding
11/01/2006                           Director/PDMR Shareholding
11/01/2006                           Director/PDMR Shareholding
12/01/2006                           Director/PDMR Shareholding
12/01/2006                           Director/PDMR Shareholding
12/01/2006                           Director/PDMR Shareholding
13/01/2006                           Director/PDMR Shareholding
16/01/2006                           Director/PDMR Shareholding
17/01/2006                           Director/PDMR Shareholding
17/01/2006                           Director/PDMR Shareholding
17/01/2006                           Directorate Change
17/01/2006                           Director/PDMR Shareholding
17/01/2006                           Director/PDMR Shareholding
19/01/2006                           Director/PDMR Shareholding
20/01/2006                           Director/PDMR Shareholding
20/01/2006                           Director/PDMR Shareholding
20/01/2006                           Director/PDMR Shareholding
20/01/2006                           Director/PDMR Shareholding
24/01/2006                           Director/PDMR Shareholding
24/01/2006                           Director/PDMR Shareholding
25/01/2006                           Director/PDMR Shareholding
26/01/2006                           Director/PDMR Shareholding
27/01/2006                           Director/PDMR Shareholding
30/01/2006                           Director/PDMR Shareholding
30/01/2006                           Director/PDMR Shareholding
31/01/2006                           Director/PDMR Shareholding
31/01/2006                           Director/PDMR Shareholding
31/01/2006                           Director/PDMR Shareholding
02/02/2006                           Director/PDMR Shareholding
02/02/2006                           Director/PDMR Shareholding
03/02/2006                           Director/PDMR Shareholding
06/02/2006                           Director/PDMR Shareholding
06/02/2006                           Director/PDMR Shareholding
06/02/2006                           Directorate Change
06/02/2006                           Directorate Change
07/02/2006                           Director/PDMR Shareholding
08/02/2006                           Final Results
09/02/2006                           Director/PDMR Shareholding
09/02/2006                           Director/PDMR Shareholding
13/02/2006                           Director/PDMR Shareholding
13/02/2006                           Director/PDMR Shareholding
13/02/2006                           Director/PDMR Shareholding
14/02/2006                           Director/PDMR Shareholding
14/02/2006                           Director/PDMR Shareholding
14/02/2006                           Director/PDMR Shareholding
14/02/2006                           Acquisition of Pliva's Research Institute
16/02/2006                           Transaction in Own Shares
16/02/2006                           Director/PDMR Shareholding
17/02/2006                           Director/PDMR Shareholding
17/02/2006                           Director/PDMR Shareholding
20/02/2006                           Director/PDMR Shareholding
20/02/2006                           Director/PDMR Shareholding
20/02/2006                           Director/PDMR Shareholding
20/02/2006                           Director/PDMR Shareholding
20/02/2006                           Transaction in Own Shares
21/02/2006                           Transaction in Own Shares
22/02/2006                           Director/PDMR Shareholding
22/02/2006                           Transaction in Own Shares
22/02/2006                           Director/PDMR Shareholding
23/02/2006                           Director/PDMR Shareholding
24/02/2006                           Director/PDMR Shareholding
24/02/2006                           Director/PDMR Shareholding
24/02/2006                           Director/PDMR Shareholding
27/02/2006                           Transaction in Own Shares
27/02/2006                           Director/PDMR Shareholding
27/02/2006                           Director/PDMR Shareholding
28/02/2006                           Director/PDMR Shareholding
28/02/2006                           Director/PDMR Shareholding
28/02/2006                           Director/PDMR Shareholding
28/02/2006                           Transaction in Own Shares
01/03/2006                           Transaction in Own Shares
02/03/2006                           Director/PDMR Shareholding
02/03/2006                           Director/PDMR Shareholding
03/03/2006                           Annual Report and Accounts
06/03/2006                           Director/PDMR Shareholding
07/03/2006                           Director/PDMR Shareholding
09/03/2006                           Transaction in Own Shares
09/03/2006                           Director/PDMR Shareholding
10/03/2006                           Director/PDMR Shareholding
10/03/2006                           Director/PDMR Shareholding
10/03/2006                           Transaction in Own Shares
13/03/2006                           Director/PDMR Shareholding
13/03/2006                           Director/PDMR Shareholding
13/03/2006                           Transaction in Own Shares
14/03/2006                           Director/PDMR Shareholding
14/03/2006                           Director/PDMR Shareholding
14/03/2006                           Director/PDMR Shareholding
14/03/2006                           Transaction in Own Shares
15/03/2006                           Transaction in Own Shares
16/03/2006                           Director/PDMR Shareholding
16/03/2006                           Transaction in Own Shares
17/03/2006                           Director/PDMR Shareholding
17/03/2006                           Director/PDMR Shareholding
20/03/2006                           Director/PDMR Shareholding
20/03/2006                           Transaction in Own Shares
21/03/2006                           Transaction in Own Shares
21/03/2006                           Director/PDMR Shareholding
22/03/2006                           Director/PDMR Shareholding
22/03/2006                           Director/PDMR Shareholding
22/03/2006                           Director/PDMR Shareholding
23/03/2006                           Transaction in Own Shares
23/03/2006                           Director/PDMR Shareholding
23/03/2006                           Notice of AGM
24/03/2006                           Transaction in Own Shares
24/03/2006                           Director/PDMR Shareholding
24/03/2006                           Director/PDMR Shareholding
27/03/2006                           Transaction in Own Shares
27/03/2006                           Director/PDMR Shareholding
27/03/2006                           Director/PDMR Shareholding
28/03/2006                           Director/PDMR Shareholding
28/03/2006                           Director/PDMR Shareholding
28/03/2006                           Transaction in Own Shares
28/03/2006                           Seretide COPD Study Results
29/03/2006                           Transaction in Own Shares
30/03/2006                           Director/PDMR Shareholding
30/03/2006                           Transaction in Own Shares




2.                         Documents filed at Companies House

All documents listed below were filed with the Registrar of Companies in England
and Wales on or around the dates indicated, and can be obtained from Companies
House via their website www.companieshouse.gov.uk

Date                     Document Type             Description of Document Filed

29/03/2005    88(2)R             Return of Allotment of Shares
29/03/2005    88(2)R             Return of Allotment of Shares
29/03/2005    88(2)R             Return of Allotment of Shares
29/03/2005    88(2)R             Return of Allotment of Shares
29/03/2005    88(2)R             Return of Allotment of Shares
29/03/2005    88(2)R             Return of Allotment of Shares
29/03/2005    88(2)R             Return of Allotment of Shares
29/03/2005    88(2)R             Return of Allotment of Shares
29/03/2005    88(2)R             Return of Allotment of Shares
29/03/2005    88(2)R             Return of Allotment of Shares
30/03/2005    88(2)R             Return of Allotment of Shares
30/03/2005    88(2)R             Return of Allotment of Shares
30/03/2005    88(2)R             Return of Allotment of Shares
30/03/2005    88(2)R             Return of Allotment of Shares
04/04/2005    88(2)R             Return of Allotment of Shares
04/04/2005    88(2)R             Return of Allotment of Shares
05/04/2005    88(2)R             Return of Allotment of Shares
05/04/2005    88(2)R             Return of Allotment of Shares
05/04/2005    88(2)R             Return of Allotment of Shares
05/04/2005    169(1B)            Return by a public company purchasing its own shares for holding in treasury
11/04/2005    288b               Resignation of Director - John Coombe
12/04/2005    88(2)R             Return of Allotment of Shares
12/04/2005    88(2)R             Return of Allotment of Shares
12/04/2005    88(2)R             Return of Allotment of Shares
12/04/2005    88(2)R             Return of Allotment of Shares
12/04/2005    88(2)R             Return of Allotment of Shares
13/04/2005    288a               Appointment of Director - Julian Heslop
14/04/2005    88(2)R             Return of Allotment of Shares
21/04/2005    169(1B)            Return by a public company purchasing its own shares for holding in treasury
21/04/2005    88(2)R             Return of Allotment of Shares
22/04/2005    88(2)R             Return of Allotment of Shares
22/04/2005    88(2)R             Return of Allotment of Shares
22/04/2005    88(2)R             Return of Allotment of Shares
22/04/2005    88(2)R             Return of Allotment of Shares
22/04/2005    88(2)R             Return of Allotment of Shares
22/04/2005    88(2)R             Return of Allotment of Shares
22/04/2005    88(2)R             Return of Allotment of Shares
22/04/2005    88(2)R             Return of Allotment of Shares
22/04/2005    88(2)R             Return of Allotment of Shares
22/04/2005    88(2)R             Return of Allotment of Shares
22/04/2005    88(2)R             Return of Allotment of Shares
22/04/2005    88(2)R             Return of Allotment of Shares
22/04/2005    88(2)R             Return of Allotment of Shares
22/04/2005    88(2)R             Return of Allotment of Shares
22/04/2005    88(2)R             Return of Allotment of Shares
22/04/2005    88(2)R             Return of Allotment of Shares
22/04/2005    88(2)R             Return of Allotment of Shares
05/05/2005    88(2)R             Return of Allotment of Shares
05/05/2005    88(2)R             Return of Allotment of Shares
05/05/2005    88(2)R             Return of Allotment of Shares
05/05/2005    169(1B)            Return by a public company purchasing its own shares for holding in treasury
06/05/2005    88(2)R             Return of Allotment of Shares
10/05/2005    AA                 Directors' Report and Accounts
11/05/2005    88(2)R             Return of Allotment of Shares
11/05/2005    88(2)R             Return of Allotment of Shares
11/05/2005    88(2)R             Return of Allotment of Shares
11/05/2005    88(2)R             Return of Allotment of Shares
11/05/2005    88(2)R             Return of Allotment of Shares
11/05/2005    88(2)R             Return of Allotment of Shares
11/05/2005    88(2)R             Return of Allotment of Shares
12/05/2005    88(2)R             Return of Allotment of Shares
16/05/2005    288c               Change of Particulars of Director
18/05/2005    PROSP              Listing of Particulars
20/05/2005    88(2)R             Return of Allotment of Shares
20/05/2005    88(2)R             Return of Allotment of Shares
20/05/2005    88(2)R             Return of Allotment of Shares
20/05/2005    88(2)R             Return of Allotment of Shares
20/05/2005    88(2)R             Return of Allotment of Shares
20/05/2005    88(2)R             Return of Allotment of Shares
20/05/2005    88(2)R             Return of Allotment of Shares
20/05/2005    88(2)R             Return of Allotment of Shares
20/05/2005    88(2)R             Return of Allotment of Shares
03/06/2005    88(2)R             Return of Allotment of Shares
03/06/2005    88(2)R             Return of Allotment of Shares
06/06/2005    88(2)R             Return of Allotment of Shares
06/06/2005    88(2)R             Return of Allotment of Shares
06/06/2005    88(2)R             Return of Allotment of Shares
06/06/2005    88(2)R             Return of Allotment of Shares
06/06/2005    88(2)R             Return of Allotment of Shares
06/06/2005    88(2)R             Return of Allotment of Shares
06/06/2005    88(2)R             Return of Allotment of Shares
06/06/2005    88(2)R             Return of Allotment of Shares
06/06/2005    88(2)R             Return of Allotment of Shares
06/06/2005    88(2)R             Return of Allotment of Shares
06/06/2005    88(2)R             Return of Allotment of Shares
06/06/2005    88(2)R             Return of Allotment of Shares
08/06/2005    MEM/ARTS           Articles of Association
08/06/2005    RES01              Special Resolutions
09/06/2005    88(2)R             Return of Allotment of Shares
09/06/2005    88(2)R             Return of Allotment of Shares
09/06/2005    88(2)R             Return of Allotment of Shares
09/06/2005    88(2)R             Return of Allotment of Shares
09/06/2005    88(2)R             Return of Allotment of Shares
09/06/2005    88(2)R             Return of Allotment of Shares
09/06/2005    88(2)R             Return of Allotment of Shares
09/06/2005    88(2)R             Return of Allotment of Shares
09/06/2005    88(2)R             Return of Allotment of Shares
17/06/2005    88(2)R             Return of Allotment of Shares
17/06/2005    88(2)R             Return of Allotment of Shares
18/06/2005    169(1B)            Return by a public company purchasing its own shares for holding in treasury
18/06/2005    169(1B)            Return by a public company purchasing its own shares for holding in treasury
29/06/2005    169(1B)            Return by a public company purchasing its own shares for holding in treasury
07/07/2005    88(2)R             Return of Allotment of Shares
18/07/2005    169(1B)            Return by a public company purchasing its own shares for holding in treasury
19/07/2005    169(1B)            Return by a public company purchasing its own shares for holding in treasury
26/07/2005    88(2)R             Return of Allotment of Shares
26/07/2005    88(2)R             Return of Allotment of Shares
26/07/2005    88(2)R             Return of Allotment of Shares
26/07/2005    88(2)R             Return of Allotment of Shares
26/07/2005    88(2)R             Return of Allotment of Shares
26/07/2005    88(2)R             Return of Allotment of Shares
26/07/2005    88(2)R             Return of Allotment of Shares
26/07/2005    88(2)R             Return of Allotment of Shares
29/07/2005    169(1B)            Return by a public company purchasing its own shares for holding in treasury
01/08/2005    88(2)R             Return of Allotment of Shares
01/08/2005    88(2)R             Return of Allotment of Shares
01/08/2005    88(2)R             Return of Allotment of Shares
12/08/2005    88(2)R             Return of Allotment of Shares
12/08/2005    88(2)R             Return of Allotment of Shares
12/08/2005    88(2)R             Return of Allotment of Shares
12/08/2005    88(2)R             Return of Allotment of Shares
12/08/2005    88(2)R             Return of Allotment of Shares
15/08/2005    88(2)R             Return of Allotment of Shares
15/08/2005    88(2)R             Return of Allotment of Shares
15/08/2005    88(2)R             Return of Allotment of Shares
15/08/2005    88(2)R             Return of Allotment of Shares
15/08/2005    88(2)R             Return of Allotment of Shares
15/08/2005    88(2)R             Return of Allotment of Shares
15/08/2005    88(2)R             Return of Allotment of Shares
15/08/2005    88(2)R             Return of Allotment of Shares
15/08/2005    88(2)R             Return of Allotment of Shares
17/08/2005    88(2)R             Return of Allotment of Shares
17/08/2005    88(2)R             Return of Allotment of Shares
17/08/2005    88(2)R             Return of Allotment of Shares
17/08/2005    88(2)R             Return of Allotment of Shares
17/08/2005    88(2)R             Return of Allotment of Shares
17/08/2005    88(2)R             Return of Allotment of Shares
17/08/2005    88(2)R             Return of Allotment of Shares
17/08/2005    88(2)R             Return of Allotment of Shares
17/08/2005    88(2)R             Return of Allotment of Shares
17/08/2005    88(2)R             Return of Allotment of Shares
17/08/2005    88(2)R             Return of Allotment of Shares
17/08/2005    88(2)R             Return of Allotment of Shares
17/08/2005    88(2)R             Return of Allotment of Shares
17/08/2005    88(2)R             Return of Allotment of Shares
17/08/2005    88(2)R             Return of Allotment of Shares
17/08/2005    88(2)R             Return of Allotment of Shares
17/08/2005    88(2)R             Return of Allotment of Shares
17/08/2005    88(2)R             Return of Allotment of Shares
17/08/2005    88(2)R             Return of Allotment of Shares
17/08/2005    88(2)R             Return of Allotment of Shares
17/08/2005    88(2)R             Return of Allotment of Shares
17/08/2005    88(2)R             Return of Allotment of Shares
17/08/2005    88(2)R             Return of Allotment of Shares
18/08/2005    88(2)R             Return of Allotment of Shares
06/09/2005    88(2)R             Return of Allotment of Shares
14/09/2005    169(1B)            Return by a public company purchasing its own shares for holding in treasury
15/09/2005    88(2)R             Return of Allotment of Shares
15/09/2005    88(2)R             Return of Allotment of Shares
15/09/2005    88(2)R             Return of Allotment of Shares
15/09/2005    88(2)R             Return of Allotment of Shares
15/09/2005    88(2)R             Return of Allotment of Shares
15/09/2005    88(2)R             Return of Allotment of Shares
15/09/2005    88(2)R             Return of Allotment of Shares
15/09/2005    88(2)R             Return of Allotment of Shares
15/09/2005    88(2)R             Return of Allotment of Shares
15/09/2005    88(2)R             Return of Allotment of Shares
15/09/2005    88(2)R             Return of Allotment of Shares
15/09/2005    88(2)R             Return of Allotment of Shares
15/09/2005    88(2)R             Return of Allotment of Shares
15/09/2005    88(2)R             Return of Allotment of Shares
15/09/2005    88(2)R             Return of Allotment of Shares
15/09/2005    88(2)R             Return of Allotment of Shares
15/09/2005    88(2)R             Return of Allotment of Shares
15/09/2005    88(2)R             Return of Allotment of Shares
15/09/2005    88(2)R             Return of Allotment of Shares
15/09/2005    88(2)R             Return of Allotment of Shares
15/09/2005    88(2)R             Return of Allotment of Shares
15/09/2005    88(2)R             Return of Allotment of Shares
15/09/2005    88(2)R             Return of Allotment of Shares
15/09/2005    88(2)R             Return of Allotment of Shares
20/09/2005    169(1B)            Return by a public company purchasing its own shares for holding in treasury
23/09/2005    88(2)R             Return of Allotment of Shares
23/09/2005    88(2)R             Return of Allotment of Shares
23/09/2005    88(2)R             Return of Allotment of Shares
29/09/2005    169(1B)            Return by a public company purchasing its own shares for holding in treasury
14/10/2005    169(1B)            Return by a public company purchasing its own shares for holding in treasury
24/10/2005    88(2)R             Return of Allotment of Shares
24/10/2005    88(2)R             Return of Allotment of Shares
02/11/2005    169(1B)            Return by a public company purchasing its own shares for holding in treasury
03/11/2005    88(2)R             Return of Allotment of Shares
03/11/2005    88(2)R             Return of Allotment of Shares
03/11/2005    88(2)R             Return of Allotment of Shares
03/11/2005    88(2)R             Return of Allotment of Shares
03/11/2005    88(2)R             Return of Allotment of Shares
03/11/2005    88(2)R             Return of Allotment of Shares
03/11/2005    88(2)R             Return of Allotment of Shares
03/11/2005    88(2)R             Return of Allotment of Shares
03/11/2005    88(2)R             Return of Allotment of Shares
03/11/2005    88(2)R             Return of Allotment of Shares
03/11/2005    88(2)R             Return of Allotment of Shares
03/11/2005    88(2)R             Return of Allotment of Shares
03/11/2005    88(2)R             Return of Allotment of Shares
03/11/2005    88(2)R             Return of Allotment of Shares
03/11/2005    88(2)R             Return of Allotment of Shares
03/11/2005    88(2)R             Return of Allotment of Shares
03/11/2005    88(2)R             Return of Allotment of Shares
03/11/2005    88(2)R             Return of Allotment of Shares
03/11/2005    88(2)R             Return of Allotment of Shares
03/11/2005    88(2)R             Return of Allotment of Shares
03/11/2005    88(2)R             Return of Allotment of Shares
03/11/2005    88(2)R             Return of Allotment of Shares
03/11/2005    88(2)R             Return of Allotment of Shares
03/11/2005    88(2)R             Return of Allotment of Shares
03/11/2005    88(2)R             Return of Allotment of Shares
03/11/2005    88(2)R             Return of Allotment of Shares
03/11/2005    88(2)R             Return of Allotment of Shares
03/11/2005    88(2)R             Return of Allotment of Shares
03/11/2005    88(2)R             Return of Allotment of Shares
03/11/2005    88(2)R             Return of Allotment of Shares
03/11/2005    88(2)R             Return of Allotment of Shares
03/11/2005    88(2)R             Return of Allotment of Shares
03/11/2005    88(2)R             Return of Allotment of Shares
03/11/2005    88(2)R             Return of Allotment of Shares
03/11/2005    88(2)R             Return of Allotment of Shares
03/11/2005    88(2)R             Return of Allotment of Shares
03/11/2005    88(2)R             Return of Allotment of Shares
24/11/2005    88(2)R             Return of Allotment of Shares
24/11/2005    88(2)R             Return of Allotment of Shares
28/11/2005    88(2)R             Return of Allotment of Shares
28/11/2005    88(2)R             Return of Allotment of Shares
28/11/2005    88(2)R             Return of Allotment of Shares
28/11/2005    88(2)R             Return of Allotment of Shares
28/11/2005    88(2)R             Return of Allotment of Shares
28/11/2005    88(2)R             Return of Allotment of Shares
28/11/2005    88(2)R             Return of Allotment of Shares
28/11/2005    88(2)R             Return of Allotment of Shares
28/11/2005    88(2)R             Return of Allotment of Shares
28/11/2005    88(2)R             Return of Allotment of Shares
28/11/2005    88(2)R             Return of Allotment of Shares
28/11/2005    88(2)R             Return of Allotment of Shares
28/11/2005    88(2)R             Return of Allotment of Shares
28/11/2005    88(2)R             Return of Allotment of Shares
28/11/2005    88(2)R             Return of Allotment of Shares
28/11/2005    88(2)R             Return of Allotment of Shares
28/11/2005    88(2)R             Return of Allotment of Shares
28/11/2005    88(2)R             Return of Allotment of Shares
28/11/2005    88(2)R             Return of Allotment of Shares
28/11/2005    88(2)R             Return of Allotment of Shares
28/11/2005    88(2)R             Return of Allotment of Shares
28/11/2005    88(2)R             Return of Allotment of Shares
28/11/2005    88(2)R             Return of Allotment of Shares
08/12/2005    169(1B)            Return by a public company purchasing its own shares for holding in treasury
10/01/2006    88(2)R             Return of Allotment of Shares
10/01/2006    88(2)R             Return of Allotment of Shares
10/01/2006    88(2)R             Return of Allotment of Shares
10/01/2006    88(2)R             Return of Allotment of Shares
10/01/2006    88(2)R             Return of Allotment of Shares
10/01/2006    88(2)R             Return of Allotment of Shares
10/01/2006    88(2)R             Return of Allotment of Shares
10/01/2006    88(2)R             Return of Allotment of Shares
10/01/2006    88(2)R             Return of Allotment of Shares
10/01/2006    88(2)R             Return of Allotment of Shares
10/01/2006    88(2)R             Return of Allotment of Shares
10/01/2006    88(2)R             Return of Allotment of Shares
10/01/2006    88(2)R             Return of Allotment of Shares
10/01/2006    88(2)R             Return of Allotment of Shares
10/01/2006    88(2)R             Return of Allotment of Shares
10/01/2006    88(2)R             Return of Allotment of Shares
10/01/2006    88(2)R             Return of Allotment of Shares
10/01/2006    88(2)R             Return of Allotment of Shares
10/01/2006    88(2)R             Return of Allotment of Shares
10/01/2006    88(2)R             Return of Allotment of Shares
10/01/2006    88(2)R             Return of Allotment of Shares
10/01/2006    88(2)R             Return of Allotment of Shares
10/01/2006    88(2)R             Return of Allotment of Shares
10/01/2006    88(2)R             Return of Allotment of Shares
10/01/2006    88(2)R             Return of Allotment of Shares
10/01/2006    88(2)R             Return of Allotment of Shares
10/01/2006    88(2)R             Return of Allotment of Shares
11/01/2006    88(2)R             Return of Allotment of Shares
11/01/2006    88(2)R             Return of Allotment of Shares
11/01/2006    88(2)R             Return of Allotment of Shares
13/01/2006    169(1B)            Return by a public company purchasing its own shares for holding in treasury
13/01/2006    363s               Annual Return
24/01/2006    169(1B)            Return by a public company purchasing its own shares for holding in treasury
08/02/2006    88(2)R             Return of Allotment of Shares
08/02/2006    88(2)R             Return of Allotment of Shares
08/02/2006    88(2)R             Return of Allotment of Shares
08/02/2006    88(2)R             Return of Allotment of Shares
08/02/2006    88(2)R             Return of Allotment of Shares
08/02/2006    88(2)R             Return of Allotment of Shares
08/02/2006    88(2)R             Return of Allotment of Shares
08/02/2006    88(2)R             Return of Allotment of Shares
08/02/2006    88(2)R             Return of Allotment of Shares
08/02/2006    88(2)R             Return of Allotment of Shares
08/02/2006    88(2)R             Return of Allotment of Shares
08/02/2006    88(2)R             Return of Allotment of Shares
08/02/2006    88(2)R             Return of Allotment of Shares
08/02/2006    88(2)R             Return of Allotment of Shares
08/02/2006    88(2)R             Return of Allotment of Shares
08/02/2006    88(2)R             Return of Allotment of Shares
08/02/2006    88(2)R             Return of Allotment of Shares
08/02/2006    88(2)R             Return of Allotment of Shares
08/02/2006    88(2)R             Return of Allotment of Shares
08/02/2006    88(2)R             Return of Allotment of Shares
08/02/2006    88(2)R             Return of Allotment of Shares
08/02/2006    88(2)R             Return of Allotment of Shares
08/02/2006    88(2)R             Return of Allotment of Shares
08/02/2006    88(2)R             Return of Allotment of Shares
08/02/2006    88(2)R             Return of Allotment of Shares
08/02/2006    88(2)R             Return of Allotment of Shares
08/02/2006    88(2)R             Return of Allotment of Shares
08/02/2006    88(2)R             Return of Allotment of Shares
08/02/2006    88(2)R             Return of Allotment of Shares
08/02/2006    88(2)R             Return of Allotment of Shares
08/02/2006    88(2)R             Return of Allotment of Shares
14/02/2006    288c               Change of Particulars of Secretary
17/02/2006    88(2)R             Return of Allotment of Shares
17/02/2006    88(2)R             Return of Allotment of Shares
17/02/2006    88(2)R             Return of Allotment of Shares
17/02/2006    88(2)R             Return of Allotment of Shares
17/02/2006    88(2)R             Return of Allotment of Shares
17/02/2006    88(2)R             Return of Allotment of Shares
17/02/2006    88(2)R             Return of Allotment of Shares
17/02/2006    88(2)R             Return of Allotment of Shares
17/02/2006    88(2)R             Return of Allotment of Shares
17/02/2006    88(2)R             Return of Allotment of Shares
17/02/2006    88(2)R             Return of Allotment of Shares
17/02/2006    88(2)R             Return of Allotment of Shares
17/02/2006    88(2)R             Return of Allotment of Shares
21/03/2006    88(2)R             Return of Allotment of Shares
21/03/2006    88(2)R             Return of Allotment of Shares
21/03/2006    88(2)R             Return of Allotment of Shares
21/03/2006    88(2)R             Return of Allotment of Shares
21/03/2006    88(2)R             Return of Allotment of Shares
21/03/2006    88(2)R             Return of Allotment of Shares
21/03/2006    88(2)R             Return of Allotment of Shares
21/03/2006    88(2)R             Return of Allotment of Shares
21/03/2006    88(2)R             Return of Allotment of Shares
21/03/2006    88(2)R             Return of Allotment of Shares
21/03/2006    88(2)R             Return of Allotment of Shares
21/03/2006    88(2)R             Return of Allotment of Shares
21/03/2006    88(2)R             Return of Allotment of Shares
21/03/2006    88(2)R             Return of Allotment of Shares
21/03/2006    88(2)R             Return of Allotment of Shares
21/03/2006    88(2)R             Return of Allotment of Shares
21/03/2006    88(2)R             Return of Allotment of Shares
21/03/2006    88(2)R             Return of Allotment of Shares
21/03/2006    88(2)R             Return of Allotment of Shares
21/03/2006    88(2)R             Return of Allotment of Shares
21/03/2006    88(2)R             Return of Allotment of Shares
21/03/2006    88(2)R             Return of Allotment of Shares
21/03/2006    88(2)R             Return of Allotment of Shares
21/03/2006    88(2)R             Return of Allotment of Shares
21/03/2006    88(2)R             Return of Allotment of Shares
21/03/2006    88(2)R             Return of Allotment of Shares
21/03/2006    88(2)R             Return of Allotment of Shares
21/03/2006    88(2)R             Return of Allotment of Shares
30/03/2006    169(1B)            Return by a public company purchasing its own shares for holding in treasury


3.     Documents filed with the Securities and Exchange Commission ("SEC")

The Company submitted filings to the SEC in compliance with its obligations
under national laws and rules dealing with the regulation of securities, issuers
of securities and securities markets  by virtue of having American Depository
Shares admitted to trading on the New York Stock Exchange. Full details of 
these filings can be found on the SEC's website at www.sec.gov

4.                     Documents sent to shareholders

The following documents were published and sent to shareholders. They are
available on the Company's website.

Date                                      Document

03/03/2006                            Annual Report and Accounts

03/03/2006                            Annual Review

23/03/2006                            Notice of Annual General Meeting



A copy of this Annual Information Update and copies of the documents referred to
in it can be obtained from the Deputy Company Secretary at the Company's
registered office:

Victoria Whyte
Deputy Company Secretary
GlaxoSmithKline plc
980 Great West Road
Brentford
Middlesex
TW8 9GS

Tel: [phone]


                      This information is provided by RNS
            The company news service from the London Stock Exchange