Director/PDMR Shareholding

GlaxoSmithKline PLC
19 December 2005






   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons



I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.


   1 November 2005               Abacus (GSK) Trustees Limited, as trustee of the
                                 GlaxoSmithKline Employee Trust, ("the GSK Trust"), sold 1,718
                                 Ordinary Shares in the Company on behalf of participants in the
                                 SmithKline Beecham Mid-Term Incentive Plan at a price of
                                 £14.6636 per share.



The Company was advised of this transaction on 2 November 2005.


   16 November 2005              Abacus (GSK) Trustees Limited, as trustee of the GSK Trust,
                                 transferred 9,005 Ordinary Shares in the Company to
                                 participants in the SmithKline Beecham Employee Share Option
                                 Plan 1991.


   17 November 2005              Abacus (GSK) Trustees Limited, as trustee of the GSK Trust,
                                 transferred 2,470 Ordinary Shares in the Company to
                                 participants in the SmithKline Beecham Mid-Term Incentive Plan.



The Company was advised of these transactions on 17 November 2005.



The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Three of the Company's directors, Dr J-P Garnier, Dr T Yamada and
Mr J S Heslop are therefore interested in the shares held in the GSK Trust from
time to time in the same way as other employees or former employees of
GlaxoSmithKline plc and its subsidiaries.



This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).



S M Bicknell
Company Secretary


19 December 2005





                      This information is provided by RNS
            The company news service from the London Stock Exchange