Director/PDMR Shareholding

GlaxoSmithKline PLC
19 April 2006




   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons



I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.




10 April 2006              The Administrators of the SmithKline Beecham Employee
                           Benefit Trust ("the Trust") notified the Company on 
                           18 April 2006 that 18 Ordinary shares in the Company 
                           had been transferred on 10 April 2006 from the Trust 
                           to a participant in the GlaxoSmithKline Annual 
                           Investment Plan.



11 April 2006              The Trust also notified the Company on 18 April 2006
                           that 761 Ordinary shares in the Company had been
                           purchased on 11 April 2006 on behalf of participants                          
                           in the SmithKline Beecham Bonus Investment Plan at a 
                           price of £14.92.


11 April 2006              The Trust also notified the Company on 18 April 2006
                           that 9,518 Ordinary shares had been purchased on 
                           behalf of participants in the GlaxoSmithKline Annual 
                           Investment Plan at a price of £14.92.



The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, Mr J Heslop is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.



This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).



S M Bicknell
Company Secretary



19 April 2006




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