Director/PDMR Shareholding

GlaxoSmithKline PLC
25 April 2006


   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons

I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.

21 April 2006      The Administrators of the SmithKline Beecham Employee Benefit 
                   Trust ("the Trust") notified the Company on 24 April 2006 
                   that 75,164 Ordinary shares in the Company had been 
                   transferred on 21 April 2006 from the Trust to participants 
                   in the GlaxoSmithKline Annual Investment Plan.

The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, Mr J Heslop is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.

This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).

S M Bicknell
Company Secretary

25 April 2006




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