Director/PDMR Shareholding

GlaxoSmithKline PLC
04 January 2006

   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons


I give below details of changes in the directors' interests in the Ordinary
Shares and American Depository Shares (ADSs) of GlaxoSmithKline plc.

On 31 December 2005, the following Non-Executive Directors were provisionally
allocated the following awards over Ordinary Shares and American Depository
Shares (ADSs) in the Company through the Annual Re-investment of Dividends paid
throughout 2005, as listed below:

SmithKline Beecham Non-Executive Directors Retainer Fee and Share Allocation
Award - Annual Dividend Reinvestment


Non-Executive Director                No. of Ordinary  Average Price (£) No. of ADS's     Average Price
                                      Shares                                              ($)
Sir Ian Prosser                       29.174           14.73
Dr Lucy Shapiro                       47.403           14.73             15.133           50.76


GlaxoSmithKline Non-Executive Directors Automatic Share Award and Elected Share
Award - Annual Dividend Reinvestment


Non-Executive Director                No. of Ordinary  Average Price (£) No. of ADS's     Average Price
                                      Shares                                              ($)
Sir Christopher Gent                  453.226          14.73
Mr Lawrence Culp                                                         108.765          50.76
Mr Crispin Davis                      232.469          14.73
Sir Deryck Maughan                                                       13.009           50.76
Sir Ian Prosser                       341.617          14.73
Dr Ronaldo Schmitz                    317.054          14.73
Dr Lucy Shapiro                                                          65.118           50.76
Sir Robert Wilson                     45.388           14.73


The Company and the directors were informed of these allocations on 3 January
2006.

This notification relates to transactions notified in accordance with Disclosure
Rule 3.1.4R(1)(b).

S M Bicknell
Company Secretary
4 January 2006


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