Director/PDMR Shareholding

GlaxoSmithKline PLC
24 January 2006


   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons

I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.
                    
16 January 2006     The Administrators of the SmithKline Beecham Employee 
                    Benefit Trust ("the Trust") notified the Company on 
                    23 January 2006 that following reinvestment of a cash 
                    dividend paid to shareholders on 05 January 2006, 7,180 
                    Ordinary shares in the Company had been purchased on behalf 
                    of participants in the GlaxoSmithKline Annual Investment 
                    Plan at a price of £14.67 per share.

19 January 2006     The Trust notified the Company on 23 January 2006 that 471 
                    Ordinary shares in the Company had been sold on behalf of a 
                    participant in the GlaxoSmithKline Annual Investment Plan at 
                    a price of £14.33 per share.

                    The Trust also notified the Company on the 23 January 2006 
                    that 655 Ordinary shares had been transferred from the Trust 
                    to a participant in the GlaxoSmithKline Annual Investment 
                    Plan.

The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, Mr J Heslop is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.

This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1 4R (1) (b).

S M Bicknell
Company Secretary

24 January 2006


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