Director/PDMR Shareholding

GlaxoSmithKline PLC
08 May 2006






   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons



I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.


   5 May 2006                 Abacus (GSK) Trustees Limited, as trustee of the 
                              GlaxoSmithKline Employee Trust, ("the GSK Trust"), 
                              transferred 115,938 Ordinary
                              Shares in the Company on behalf of participants in 
                              the SmithKline Beecham Employee Share Option Plan
                              1991.




   5 May 2006                 The GSK Trust sold 5,797 ADRs in the Company on 
                              behalf of participants in the SmithKline Beecham
                              Mid-Term Incentive Plan at a price of $56.93 per ADR.


   5 May 2006                 The GSK Trust transferred 12,058 ADRs in the
                              Company to participants in the SmithKline Beecham 
                              Mid-Term Incentive Plan.

The Company was advised of these transactions on 8 May 2006.


The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Three of the Company's directors, Dr J-P Garnier, Dr T Yamada and
Mr J S Heslop are therefore interested in the shares held in the GSK Trust from
time to time in the same way as other employees or former employees of
GlaxoSmithKline plc and its subsidiaries.


This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).



S M Bicknell
Company Secretary
8 May 2006


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