Director/PDMR Shareholding

GlaxoSmithKline PLC
27 September 2005


   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons


Following a re-valuation of the cash element of the notional investment held
within the US Retirement Savings Plan ("The Plan"), which is notionally held in
GSK Ordinary Share ADRs, the Administrators of the Plan notified GlaxoSmithKline
plc and the under-mentioned person on 27 September 2005 of an increase in the
notional allocation of Ordinary Share ADRs on 23 September 2005 at a price of
$50.67 per share:-

Mr R Greig                                                             2


This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(a).

S M Bicknell
Company Secretary
27 September 2005


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