Director/PDMR Shareholding

GlaxoSmithKline PLC
03 October 2005


   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons


I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.

                         
27 September 2005        The Administrators of the SmithKline Beecham Employee 
                         Benefit Trust ("the Trust") notified the Company on 03 
                         October 2005 that 237 Ordinary shares in the Company 
                         had been sold on 27 September 2005 on behalf of a 
                         participant in the GlaxoSmithKline Annual Investment 
                         Plan at a price of £14.3236 per share.

                         The Trust also notified the Company on 03 October 2005 
                         that 770 Ordinary shares had been transferred from the 
                         Trust to a participant in the GlaxoSmithKline Annual 
                         Investment Plan.

The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, Mr J Heslop is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.

This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).


S M Bicknell
Company Secretary

03 October 2005


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