Director/PDMR Shareholding

GlaxoSmithKline PLC
06 February 2006


   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons

I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.

3 February 2006       The Administrators of the SmithKline Beecham Employee 
                      Benefit Trust ("the Trust") notified the Company on 
                      6 February 2006 that 3,800 Ordinary shares in the Company 
                      had been sold on behalf of a participant in the 
                      GlaxoSmithKline Annual Investment Plan at a price of 
                      £14.52 per share.

                      The Trust also notified the Company on the 6 February 2006 
                      that 12,794 Ordinary shares had been transferred from the 
                      Trust to a participant in the GlaxoSmithKline Annual 
                      Investment Plan.

The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, Mr J Heslop is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.

This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1 4R (1) (b).

S M Bicknell
Company Secretary

6 February 2006


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