Director/PDMR Shareholding

GlaxoSmithKline PLC
09 February 2007



   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons


I give below details of changes in interests in the Ordinary shares and American
Depositary Shares (ADSs) of GlaxoSmithKline plc in respect of the
under-mentioned Directors, Persons Discharging Managerial Responsibility and
Connected Persons:-
                    
Dr J-P Garnier      Exercise of options on 8 February 2007 over 68,411 ADSs 
                    granted on 24 March 1997, which would have lapsed on 23 
                    March 2007, under the SmithKline Beecham Employee Share 
                    Option Plan 1991 at a price of $32.09 per ADS.

                    The sale of 51,100 ADSs on 8 February 2007 at an average 
                    price of $55.81.

                    Following this transaction Dr Garnier's total shareholding 
                    in the Company is 556,198 ADSs, which includes 248,448 ADSs 
                    that have been earned but deferred under the share 
                    programmes operated by the Company. At the price at which
                    the above options were exercised, Dr Garnier's holding is 
                    equivalent to more than 17 times his annual basic salary.


Mr J S Heslop       Purchase of 10,000 Ordinary shares on 9 February 2007 at a 
                    price of £14.51 per share.

                    Following this transaction Mr Heslop's total shareholding in 
                    the Company is 42,204 Ordinary shares. At the price at which 
                    the above shares were purchased, Mr Heslop's holding is 
                    equivalent to more than 1.5 times his annual basic salary.


Mr D Phelan         Exercise of options on 8 February 2007 over 54,623 ADSs 
                    granted on 13 November 1997, which would have lapsed on 12 
                    November 2007, under the SmithKline Beecham Employee Share 
                    Option Plan 1991 at a price of $40.54 per ADS and over 
                    95,000 ADSs granted on 3 December 2002 under the 
                    GlaxoSmithKline Employee Share Option Plan at a price of 
                    $37.25 per ADS.

                    The sale of 149,623 ADSs on 8 February 2007 at an average 
                    price of $55.81.


Mr D Stout          Exercise of options on 8 February 2007 over 4,951 ADSs 
                    granted on 24 March 1997, which would have lapsed on 23 
                    March 2007, under the SmithKline Beecham Employee Share 
                    Option Plan 1991 at a price of $32.09 per ADS.

                    The sale of 3,475 ADSs on 8 February 2007 at an average 
                    price of $55.87.


The Company was advised of these transactions on 8 and 9 February 2007.

This notification is in accordance with Disclosure Rules 3.1.4R(1)(a) and 3.1.4R
(1)(b).


S M Bicknell
Company Secretary

9 February 2007


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