Director/PDMR Shareholding

GlaxoSmithKline PLC
13 October 2005


   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons

The Administrators of the SmithKline Beecham Mid-Term Incentive Plan notified
the Company and the under-mentioned persons on 13 October 2005 of an increase in
their interests in Ordinary Share ADRs at a price of $51.51 per ADR following
the re-investment of the dividend paid to shareholders on 06 October 2005.

Dr W Calhoun                                115.476

Dr J P Garnier                              1,129.791

Mr D Phelan                                 217.901

Dr D Stout                                  87.096

Mr J Ziegler                                70.303

This notification relates to a transaction notified in accordance with
Disclosure Rules 3.1.4R(1)(a) and 3.1.4R(1)(b).

S M Bicknell
Company Secretary

13 October 2005



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