Director/PDMR Shareholding

GlaxoSmithKline PLC
17 February 2006

   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons

I give below details of changes in interests in the Ordinary Shares of
GlaxoSmithKline plc in respect of the under-mentioned Director:-

Dr L Shapiro     The Administrators of the GlaxoSmithKline Scientific Advisory 
                 Board Share Allocation Plan notified GlaxoSmithKline plc on 
                 16 February 2006 that 296 American Depository Shares (ADS) had 
                 been purchased for Dr Shapiro at a price of $51.04 on 
                 15 February 2006 as per the share election arrangements for the
                 Scientific Advisory Board.  Dr Shapiro was also notified of 
                 this change on 16 February 2006.

This notification relates to a transaction notified in accordance with
Disclosure rule 3.1.4R(1)(b).

S M Bicknell
Company Secretary

17 February 2006


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