Director/PDMR Shareholding

GlaxoSmithKline PLC
31 October 2005



   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons


I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.

   28 October 2005      Abacus (GSK) Trustees Limited, as trustee of the
                        GlaxoSmithKline Employee Trust, ("the GSK Trust"), 
                        transferred 159,134 Ordinary Shares in the Company to 
                        participants in the SmithKline Beecham Employee Share 
                        Option Plan 1991.


The Company was advised of these transactions on 31 October 2005.

The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Three of the Company's directors, Dr J-P Garnier, Dr T Yamada and
Mr J S Heslop are therefore interested in the shares held in the GSK Trust from
time to time in the same way as other employees or former employees of
GlaxoSmithKline plc and its subsidiaries.

This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).


S M Bicknell,
Company Secretary

31 October 2005



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