Director/PDMR Shareholding

GlaxoSmithKline PLC
23 November 2006

















   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons



Following a re-valuation of the cash element of the notional investment held
within the US Retirement Savings Plan ("The Plan"), which is notionally held in
GSK Ordinary Share ADRs, the Administrators of the Plan notified GlaxoSmithKline
plc and the under-mentioned person on 21 November 2006 of an increase in the
notional allocation of Ordinary Share ADRs on 17 November 2006 at a price of
$52.00 per share:-




Dr R G Greig                                                           5



This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(a).





S M Bicknell

Company Secretary



23 November 2006


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