Director/PDMR Shareholding

GlaxoSmithKline PLC
20 July 2006


   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons

I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.

   19 July 2006  Abacus Corporate Trustee Limited, as trustee of the
                 GlaxoSmithKline (US) Trust, ("the GSK US Trust"), sold 2,529
                 Ordinary Share ADRs in the Company on behalf of participants in
                 the GlaxoSmithKline Share Value Plan at a price of $53.89 per
                 ADR.

                 The GSK US Trust transferred 5,242 Ordinary Share ADRs in the
                 Company to participants in the GlaxoSmithKline Share Value
                 Plan.

The Company was advised of these transactions on 19 July 2006.

The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Three of the Company's directors, Dr J-P Garnier, Dr M M Slaoui
and Mr J S Heslop are therefore interested in the shares held in the GSK Trust
from time to time in the same way as other employees or former employees of
GlaxoSmithKline plc and its subsidiaries.

This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).

S M Bicknell
Company Secretary

20 July 2006


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