Director/PDMR Shareholding

GlaxoSmithKline PLC
01 August 2006


   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons


I give below details of changes in interests in the American Depositary Shares
(ADSs)  of GlaxoSmithKline plc in respect of the under-mentioned Person
Discharging Managerial Responsibility:-


Mr D Phelan    Exercise of options on 31 July 2006 over 23,517 ADSs granted on 
               21 November 1996 under the SmithKline Beecham Employee Share 
               Option Plan 1991 at a price of $28.159 per ADS.

               The sale of 23,517 ADSs on 31 July 2006 at an average price of 
               $55.31 per ADS.

               The Company was advised of these transactions on 1 August 2006.


These notifications are in accordance with Disclosure Rule 3.1.4R(1)(a).


S M Bicknell
Company Secretary

1 August 2006


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