Director/PDMR Shareholding

GlaxoSmithKline PLC
19 March 2007


   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons



I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares and Ordinary Share ADRs ("ADRs") of GlaxoSmithKline plc.


   14 March 2007                 Abacus (GSK) Trustees Limited, as trustee of the
                                 GlaxoSmithKline Employee Trust, ("the GSK Trust"), sold 69,039
                                 Ordinary Shares in the Company at a price of £14.21 per share
                                 on behalf of participants in the GlaxoSmithKline Performance
                                 Share Plan.


                                 The GSK Trust transferred 130,571 Ordinary Shares of
                                 GlaxoSmithKline plc to participants in the GlaxoSmithKline
                                 Performance Share Plan.


   15 March 2007                 The GSK Trust transferred 6,575 Ordinary Shares in the Company
                                 to participants in the SmithKline Beecham Employee Share Option
                                 Plan 1991.


                                 Abacus Corporate Trustees Limited, as trustee of the
                                 GlaxoSmithKline (US Trust) ("the GSK US Trust") sold 23,348
                                 ADRs at a price of $54.71 per ADR on behalf of participants in
                                 the GlaxoSmithKline Share Value Plan.


                                 The GSK US Trust transferred 38,114 ADRs of GlaxoSmithKline plc
                                 to participants in the GlaxoSmithKline Share Value Plan.


   16 March 2007                 The GSK US Trust sold 49,890 ADRs at a price of $54.86 per ADR
                                 on behalf of participants in the GlaxoSmithKline Performance
                                 Share Plan.


                                 GSK US Trust transferred 98,458 ADRs of GlaxoSmithKline plc to
                                 participants in the GlaxoSmithKline Performance Share Plan.



The Company was advised of these transactions on 16 March 2007.



The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Three of the Company's directors, Dr J-P Garnier, Dr M M Slaoui
and Mr J S Heslop are therefore interested in the shares held in the GSK Trust
from time to time in the same way as other employees or former employees of
GlaxoSmithKline plc and its subsidiaries.



The GSK US Trust is a grantor trust of which all employees or former employees
of SmithKline Beecham Corporation and its subsidiaries are potential
beneficiaries. Two of the Company's directors, Dr J-P Garnier and Dr M M Slaoui
are therefore interested in the shares held in the GSK US Trust from time to
time in the same way as other employees or former employees of SmithKline
Beecham Corporation and its subsidiaries.



This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).





S M Bicknell

Company Secretary



19 March 2007


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