Director/PDMR Shareholding

GlaxoSmithKline PLC
22 November 2005



   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons

Following a re-valuation of the cash element of the notional investment held
within the US Retirement Savings Plan ("The Plan"), which is notionally held in
GSK Ordinary Share ADRs, the Administrators of the Plan notified GlaxoSmithKline
plc and the under-mentioned person on 22 November 2005 of an increase in the
notional allocation of Ordinary Share ADRs as follows :-

As a result of movements in the fund on 18 November 2005 at a price of $52.05
per ADR

Mr R Greig                                                          6

This notification relates to a transaction notified in accordance with
Disclosure Rules 3.1.4R(1)(a).


S M Bicknell

Company Secretary

22 November 2005



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