Director/PDMR Shareholding

GlaxoSmithKline PLC
22 November 2005


   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons

I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.

                         
21 November 2005         The Administrators of the SmithKline Beecham Employee 
                         Benefit Trust ("the Trust") notified the Company on 
                         21 November 2005 that 3004 Ordinary shares in the 
                         Company had been sold on 16 November 2005 on behalf of 
                         a participant in the GlaxoSmithKline Annual Investment 
                         Plan at a price of £14.98

                         The Trust also notified the Company on 21 November 2005 
                         that 10,380 Ordinary shares had been transferred from 
                         the Trust to a participant in the GlaxoSmithKline 
                         Annual Investment Plan.

The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, Mr J Heslop is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.

This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1 4R (1) (b).


S M Bicknell
Company Secretary

22 November 2005


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