Director Shareholding

GlaxoSmithKline PLC
16 March 2001

                             Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

13    The Administrators of the SmithKline Beecham US Retirement Savings Plan
March ('the Plan') notified GlaxoSmithKline plc on the 15 March 2001, that as a
2001  result of movement in the fund on the 13 March 2001, the number of
      Ordinary share ADRs held by the fund had increased from 17,537,340 to
      17,607,542 at an average price of $53.1100.

The Plan is a discretionary fund of which all employees or former employees of
SmithKline Beecham plc and its subsidiaries are potential beneficiaries. One
of the Company's directors, Dr J P Garnier, as a director of SmithKline
Beecham plc, is therefore, interested in the shares held in the fund from time
to time in the same way as other employees or former employees of SmithKline
Beecham plc and its subsidiaries.

S M Bicknell

Company Secretary

16 March 2001