Director Shareholding

GlaxoSmithKline PLC 2 January 2001 Directors' Interests I give below details of changes in directors' interests in the Ordinary Shares of GlaxoSmithKline plc. 22nd The Administrators of the SmithKline Beecham US Retirement Savings December Plan ('the Plan') notified SmithKline Beecham plc on the 22nd December 2000 2000, that as a result of movement in the fund on the 21st and 22nd December 2000, the number of Ordinary share ADRs held by the fund had increased from 15,386,769 to 15,503,215 at an average price of $61.8750. A Director of GlaxoSmithKline plc, Dr J P Garnier, is a potential beneficiary under the Plan and is therefore deemed to have an interest in all the shares of the fund by virtue of the provisions of the Companies Act 1985. S M Bicknell Company Secretary 2nd January 2001

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