Director Shareholding

GlaxoSmithKline PLC 3 January 2001 Directors' Interests I give below details of changes in directors' interests in the Ordinary Shares of GlaxoSmithKline plc. 2nd Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome January Employee Trust ('the Trust'), sold 44,125 Ordinary Shares in the 2001 Company at £18.86 per share. The Trust is a discretionary trust of which all employees or former employees of Glaxo Wellcome plc and its subsidiaries are potential beneficiaries. Two of the Company's directors, Sir Richard Sykes and John Coombe, as directors of Glaxo Wellcome plc, are therefore interested in the shares held in the Trust from time to time in the same way as other employees or former employees of Glaxo Wellcome plc and it's subsidiaries. S M Bicknell Company Secretary 3rd January 2001

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