Director Shareholding

GlaxoSmithKline PLC
4 January 2001


                             Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

3rd      Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome
January  Employee Trust ('the Trust'), transferred 9,271 Ordinary Shares in the
2001     Company to participants of the Glaxo Wellcome 1999 Long Term Incentive
         Plan.

The Trust is a discretionary trust of which all employees or former employees
of Glaxo Wellcome plc and its subsidiaries are potential beneficiaries. Two of
the Company's directors, Sir Richard Sykes and John Coombe, as directors of
Glaxo Wellcome plc, are therefore interested in the shares held in the Trust
from time to time in the same way as other employees or former employees of
Glaxo Wellcome plc and it's subsidiaries.


S M Bicknell

Company Secretary



4th January 2001