Director Shareholding

GlaxoSmithKline PLC 23 January 2001 Directors' Interests I give below details of changes in directors' interests in the Ordinary Shares of GlaxoSmithKline plc. 22 Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome Employee January Trust ('the Trust'), transferred 18,495 Ordinary Shares in the Company 2001 to participants of the Glaxo Wellcome 1999 Share Option Plan and the Glaxo Wellcome International Share Option Scheme. The Trust also sold 46,342 Ordinary Shares in the company at a price of £17.90 per share. The Company was advised of this transaction on 23 January 2001. The Trust is a discretionary trust of which all employees or former employees of Glaxo Wellcome plc and its subsidiaries are potential beneficiaries. Two of the Company's directors, Sir Richard Sykes and John Coombe, as directors of Glaxo Wellcome plc, are therefore interested in the shares held in the Trust from time to time in the same way as other employees or former employees of Glaxo Wellcome plc and its subsidiaries. S M Bicknell Company Secretary 23 January 2001

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