Director Shareholding

GlaxoSmithKline PLC
25 January 2001


                             Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

24 January 2001    Abacus (GW) Trustees Limited, as trustee of The Glaxo 
                   Wellcome Employee Trust ('the Trust'), transferred 6,824 
                   Ordinary Shares in the Company  to participants of the Glaxo 
                   Wellcome International Share Option Scheme.


The Company was advised of this transaction on 25 January 2001.

The Trust is a discretionary trust of which all employees or former employees
of Glaxo Wellcome plc and its subsidiaries are potential beneficiaries. Two of
the Company's directors, Sir Richard Sykes and John Coombe, as directors of
Glaxo Wellcome plc, are therefore interested in the shares held in the Trust
from time to time in the same way as other employees or former employees of
Glaxo Wellcome plc and its subsidiaries.

                          
S M Bicknell

Company Secretary


25 January 2001