Director Shareholding

GlaxoSmithKline PLC
27 April 2001

                             Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

26    Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome Employee
April Trust ('the Trust'), transferred 1,834 Ordinary Shares in the Company to
2001  participants of the Glaxo Wellcome UK Share Option Plan and the Glaxo
      Wellcome International Share Option Scheme.


The Company was advised of this transaction 27 April 2001.

The Trust is a discretionary trust of which all employees or former employees
of Glaxo Wellcome plc and its subsidiaries are potential beneficiaries. Two of
the Company's directors, Sir Richard Sykes and John Coombe are therefore
interested in the shares held in the Trust from time to time in the same way
as other employees or former employees of Glaxo Wellcome plc and its
subsidiaries.

S M Bicknell

Company Secretary




27 April 2001