Director Shareholding

GlaxoSmithKline PLC 5 February 2001 Directors' Interests I give below details of changes in directors' interests in the Ordinary Shares of GlaxoSmithKline plc. 1 Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome February Employee Trust ('the Trust'), transferred 78,431 Ordinary Shares in 2001 the Company to participants of the Glaxo Wellcome Long Term Incentive Plan, The Glaxo Wellcome 1999 Share Option Plan and the Glaxo Wellcome International Share Option Scheme. The Company was advised of this transaction on 2 February 2001. The Trust is a discretionary trust of which all employees or former employees of Glaxo Wellcome plc and its subsidiaries are potential beneficiaries. Two of the Company's directors, Sir Richard Sykes and John Coombe, as directors of Glaxo Wellcome plc, are therefore interested in the shares held in the Trust from time to time in the same way as other employees or former employees of Glaxo Wellcome plc and its subsidiaries. S M Bicknell Company Secretary 5 February 2001

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