Director Shareholding

GlaxoSmithKline PLC
5 April 2001

                             Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

4     Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome Employee
April Trust ('the Trust'), transferred 5,857 Ordinary Shares in the Company to
2001  participants of the Glaxo Wellcome 1999 Share Option Plan, the Glaxo
      Wellcome UK Share Option Scheme and the Glaxo Wellcome International
      Share Option Scheme.



The Company was advised of this transaction 5 April 2001.


The Trust is a discretionary trust of which all employees or former employees
of Glaxo Wellcome plc and its subsidiaries are potential beneficiaries. Two of
the Company's directors, Sir Richard Sykes and John Coombe are therefore
interested in the shares held in the Trust from time to time in the same way
as other employees or former employees of Glaxo Wellcome plc and its
subsidiaries.


S M Bicknell

Company Secretary


5 April 2001