Director Shareholding

GlaxoSmithKline PLC 21 March 2001 Directors' Interests I give below details of changes in directors' interests in the Ordinary Shares of GlaxoSmithKline plc. 20 Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome Employee March Trust ('the Trust'), purchased 556,657 Ordinary Shares in the Company 2001 at a price of £17.6436 per share. The Company was advised of this transaction 21 March 2001. The Trust is a discretionary trust of which all employees or former employees of Glaxo Wellcome plc and its subsidiaries are potential beneficiaries. Two of the Company's directors, Sir Richard Sykes and John Coombe, as directors of Glaxo Wellcome plc, are therefore interested in the shares held in the Trust from time to time in the same way as other employees or former employees of Glaxo Wellcome plc and its subsidiaries. S M Bicknell Company Secretary 21 March 2001

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