Director Shareholding

GlaxoSmithKline PLC
15 March 2001





                             Director's Interests





I give below details of changes in interests in the Ordinary Shares of
GlaxoSmithKline plc in respect of the under-mentioned directors:-


Mr John  Exercised a nominal cost option (£1.00) on 12 March 2001 to acquire
D        25,120 shares in the Company, which had vested under the Glaxo Wellcome
Coombe   1998 Long Term Incentive Plan. Mr Coombe subsequently sold 10,069 of
         the shares so acquired at a price of £18.45 per share to pay the
         resultant tax liability and to meet the costs arising from the sale.

         Sold 15,000 Ordinary Shares in the Company on 13 March 2001 at a price
         of £18.12 per share.


Sir      Disposal of 10,000 Ordinary Shares in the Company on 13 March 2001 by
Richard  way of gift.
Sykes



The Company was advised of these transactions on the 14 March 2001.





SM Bicknell

Company Secretary

15 March 2001