Director Shareholding

GlaxoSmithKline PLC
3 August 2001


                             Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.
1       Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome Employee
August  Trust ('the Trust'), transferred 121,261 Ordinary Shares in the Company
2001    to participants of the Glaxo Wellcome 1999 Share Option Plan, Glaxo
        Wellcome UK Share Option Scheme and the Glaxo Wellcome International
        Share Option Scheme. The Trust also sold 4,844 Ordinary Shares in the
        Company at £20.21 per share.


The Company was advised of these transactions on 2 August 2001.

The Trust is a discretionary trust of which all employees or former employees
of Glaxo Wellcome plc and its subsidiaries are potential beneficiaries. Two of
the Company's directors, Sir Richard Sykes and John Coombe are therefore
interested in the shares held in the Trust from time to time in the same way
as other employees or former employees of Glaxo Wellcome plc and its
subsidiaries.


S M Bicknell

Company Secretary

3 August 2001