Director Shareholding

GlaxoSmithKline PLC
13 September 2001

                             Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


12          Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome
September   Employee Trust ('the Trust'), purchased 1,445,000 Ordinary Shares in
2001        the Company at a price of £17.114789 per share, and sold 1,557
            Ordinary Shares in the Company at a price of £17.31 per share. The
            Trust also transferred 17,694 Ordinary Shares to participants of the
            Glaxo Wellcome International Share Option Scheme and the Glaxo
            Wellcome 1999 Long Term Incentive Plan.




The Company was advised of these transactions on 13 September 2001.


The Trust is a discretionary trust of which all employees or former employees
of Glaxo Wellcome plc and its subsidiaries are potential beneficiaries. Two of
the Company's directors, Sir Richard Sykes and John Coombe are therefore
interested in the shares held in the Trust from time to time in the same way
as other employees or former employees of Glaxo Wellcome plc and its
subsidiaries.




S M Bicknell

Company Secretary




13 September 2001