Director Shareholding

GlaxoSmithKline PLC
10 September 2001

                             Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


7           Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome
September   Employee Trust ('the Trust'), purchased 2,824,721 Ordinary Shares in
2001        the Company at a price of £17.5952 per share. The Trust also
            transferred 8,998 Ordinary Shares in the Company to participants of
            the Glaxo Wellcome International Share Option Scheme.




The Company was advised of this transaction on 10 September 2001.



The Trust is a discretionary trust of which all employees or former employees
of Glaxo Wellcome plc and its subsidiaries are potential beneficiaries. Two of
the Company's directors, Sir Richard Sykes and John Coombe are therefore
interested in the shares held in the Trust from time to time in the same way
as other employees or former employees of Glaxo Wellcome plc and its
subsidiaries.





S M Bicknell

Company Secretary



10 September 2001