Director Shareholding

GlaxoSmithKline PLC
2 October 2001



                             Directors' Interests



I give below details of changes in interests in the Ordinary Shares of
GlaxoSmithKline plc in respect of the undermentioned directors:

Sir Richard Beneficial interest in 9 Ordinary Shares purchased under a Personal
Sykes       Equity Plan on 1 October 2001 at £18.95.

            Lady Janet Sykes (wife); beneficial interest in 6 Ordinary shares
            purchased under a Personal Equity Plan on 1 October 2001 at £18.95.

Mr J D      Beneficial interest in 4 Ordinary Shares purchased under a Personal
Coombe      Equity Plan on 1 October 2001 at £18.95.

            Mrs G A Coombe (wife); beneficial interest in 3 Ordinary Shares
            purchased under a Personal Equity Plan on 1 October 2001 at £18.95.

Sir Peter   Beneficial interest in 1 Ordinary Shares purchased under a Personal
Job         Equity Plan on 1 October 2001 at £18.95.

Sir         Beneficial interest in 17 Ordinary Shares purchased under a
Christopher Personal Equity Plan on 1 October 2001 at £18.95.
Hogg


The Directors and the Company were advised of these transactions on 2 October
2001.


S M Bicknell

Company Secretary

2 October 2001