Director Shareholding

GlaxoSmithKline PLC 21 September 2001 Directors' Interests I give below details of changes in directors' interests in the Ordinary Shares of GlaxoSmithKline plc. 20 The Administrators of the SmithKline Beecham US Retirement Savings September Plan ('the Plan') notified GlaxoSmithKline plc on the 21 September 2001 2001, that as a result of movement in the fund on the 20 September 2001, the number of Ordinary Share ADRs held by the fund had decreased from 18,691,686 to 18,250,080 at an average price of $51.5500. The Plan is a discretionary fund of which all employees or former employees of SmithKline Beecham plc and its subsidiaries are potential beneficiaries. One of the Company's directors, Dr J P Garnier is therefore, interested in the shares held in the fund from time to time in the same way as other employees or former employees of SmithKline Beecham plc and its subsidiaries. S M Bicknell Company Secretary 21 September 2001

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