Director Shareholding

GlaxoSmithKline PLC 24 September 2001 Directors' Interests I give below details of changes in directors' interests in the Ordinary Shares of GlaxoSmithKline plc. 21 Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome September Employee Trust ('the Trust'), purchased 2,954,134 Ordinary Shares in 2001 the Company at a price of £16.8244 per share, and 1,300,000 Ordinary Shares in the Company at a price of £17.0597 per share. The Trust also transferred 24,799 Ordinary Shares to participants of the Glaxo Wellcome International Share Option Scheme. The Company was advised of these transactions on 24 September 2001. The Trust is a discretionary trust of which all employees or former employees of Glaxo Wellcome plc and its subsidiaries are potential beneficiaries. Two of the Company's directors, Sir Richard Sykes and John Coombe are therefore interested in the shares held in the Trust from time to time in the same way as other employees or former employees of Glaxo Wellcome plc and its subsidiaries. S M Bicknell Company Secretary 24 September 2001

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