Director Shareholding

GlaxoSmithKline PLC
23 October 2001







                             Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.



18      The Administrators of the SmithKline Beecham US Retirement Savings Plan
October ('the Plan') notified GlaxoSmithKline plc on the 22 October 2001, that
2001    as a result of movement in the fund on the 18 October 2001, the number
        of Ordinary Share ADRs held by the fund had increased from 18,409,951
        to 18,433,631 at an average price of $54.8500


The Plan is a discretionary fund of which all employees or former employees of
SmithKline Beecham plc and its subsidiaries are potential beneficiaries. One
of the Company's directors, Dr J P Garnier is therefore, interested in the
shares held in the fund from time to time in the same way as other employees
or former employees of SmithKline Beecham plc and its subsidiaries.






S M Bicknell

Company Secretary


23 October 2001