Director Shareholding

GlaxoSmithKline PLC
13 September 2002

                              Directors' Interests


I give below details of a change in the interests in Ordinary Shares of
GlaxoSmithKline plc in respect of the undermentioned Director arising from the
purchase of Ordinary Shares at a price of £12.44 per Ordinary Share on 10
September 2002 through the Company's ShareReward Plan ("the Plan") which Mr
Coombe entered on 5 October 2001:


Mr J D Coombe          Acquisition of 11 Ordinary Shares under the partnership 
                       element of the Plan (personal contribution)

                       Acquisition of 11 Ordinary Shares under the matching 
                       element of the Plan (Company contribution)


Mr Coombe and the Company were advised of this information on 12 September 2002.


S M Bicknell

Company Secretary

13 September 2002


                      This information is provided by RNS
            The company news service from the London Stock Exchange