Director Shareholding

GlaxoSmithKline PLC
12 December 2002


                              Directors' Interests


I give below details of a change in the interests in Ordinary Shares of
GlaxoSmithKline plc in respect of the undermentioned Director arising from the
purchase of Ordinary Shares at a price of £11.86 per Ordinary Share on 10
December 2002 through the Company's ShareReward Plan ("the Plan") which Mr
Coombe entered on 5 October 2001:

Mr J D Coombe         Acquisition of 10 Ordinary Shares under the partnership 
                      element of the Plan (personal contribution)

                      Acquisition of 10 Ordinary Shares under the matching 
                      element of the Plan Company contribution)

Mr Coombe and the Company were advised of this information on 11 December 2002.


S M Bicknell

Company Secretary

12 December 2002


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